|
KMID : 0857020060210010323
|
|
Kosin Medical Journal
2006 Volume.21 No. 1 p.323 ~ p.327
|
|
|
he Clinical Implication of Non-Proteolytic EnzYme Activities in Stomach Cancer
|
|
Chang Hee-Kyung
Choi Jong-Soon
|
|
|
Abstract
|
|
|
Backgrounds : Beta-glucuronidase and lactic dehydrogenase are non-proteolytic enzymes related to the inflammation. In recent years there are a few reports that these 2 enzymes may be markers of gastric cancer. Material and
Methods : The study was to observe whether the measurement of enzyme activity had any critical role in assessement of diagnostic value, beta-glucuronidase and lactic dehydrogenase activities in neoplastic tissue of stomach were compared with those in the gastric muosa of non-neoplastic antral and body area, which were obtained from products of gastrectomy of 27 cases. The enzyme immunoassay was used fro the estimate of the activity of enxymes.
Results : The activity of enzymes was compared with each differentiation and metastasis of the tumor. beta-glucuronidase activity in tumor was higher that that of normal mucosa and activity of antral mucosa with intestinal metaplasia, and it was higher than that of body. Lactic dehydrogenase activity in tumor was similar to that in the antral mucosa with intestinal metaplasia, and it was higher than that in the body mucosa of stomach. There were no significant statistical difference of actvities of both enzymes between metastatic and non-metastatic groups(p>0.01). No significant correlation between activities of both enzymes was not seen in the tumor mass(r=0.347, p>0.05).
Conclusions : These results support that enzyme activities of beta-glucuronidase and LDH in gastric tissues and tumor mass could reflect the histopathologic status of stomach and the assessment of the activity of enzymes may be of value in the identification of high-risk groups.
|
|
|
KEYWORD
|
|
|
Gastric Cancer, LDH, Beta-glucuronidase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|